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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
27.27
Human Site:
Y1268
Identified Species:
50
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
Y1268
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Chimpanzee
Pan troglodytes
P61584
1003
117506
R919
R
C
H
V
K
C
H
R
D
H
L
D
K
K
E
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
Y1404
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Dog
Lupus familis
XP_540083
1519
175559
Y1399
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
Y1268
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Rat
Rattus norvegicus
Q62868
1379
159417
Y1259
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
Y1142
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Chicken
Gallus gallus
XP_419954
1438
166280
Y1318
H
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
Frog
Xenopus laevis
NP_001154860
1372
159002
F1254
F
I
P
T
L
Y
H
F
P
T
S
C
D
A
C
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
H1258
E
F
I
P
T
L
Y
H
F
P
T
N
C
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
L1426
T
L
A
I
Y
V
D
L
Q
G
R
K
S
R
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
A1089
D
I
I
R
P
T
P
A
F
E
C
K
N
C
H
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
V1213
H
K
N
H
K
F
T
V
V
H
F
H
M
P
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
100
0
0
N.A.
6.6
N.A.
26.6
6.6
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
100
13.3
6.6
N.A.
20
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
8
% A
% Cys:
0
8
0
0
0
8
0
0
0
0
8
8
8
62
8
% C
% Asp:
8
0
0
0
0
0
8
0
8
0
0
8
8
0
8
% D
% Glu:
8
54
0
0
0
0
0
0
0
8
0
0
0
8
62
% E
% Phe:
8
8
54
0
0
8
0
8
16
54
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
62
0
8
8
0
0
16
8
54
16
0
8
0
0
8
% H
% Ile:
0
16
16
62
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
16
0
0
0
0
0
0
16
8
8
0
% K
% Leu:
0
8
0
0
8
8
54
8
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
8
62
0
0
% N
% Pro:
0
0
8
8
62
0
8
0
8
8
54
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
0
0
8
0
0
0
8
0
0
8
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% S
% Thr:
8
0
0
8
8
62
8
0
0
8
8
54
0
0
8
% T
% Val:
0
0
0
8
0
8
0
8
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
8
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _